Dihydromunduletone (DHM) 是类胡萝卜素衍生物，是一种选择性，有效的粘附 G 蛋白偶联受体 (aGPCR) (GPR56 and GPR114/ADGRG5) 拮抗剂，对 GPR56 的 IC 50 值为 20.9 μM，但不抑制 GPR110 或 A 类 GPCR。
| Cas No. | 674786-20-0 |
| 别名 | DHM |
| Canonical SMILES | CC1(C)C=CC2=C(OC)C(CC(C3=C(O)C=C4C(CC(O)C(C)(C)O4)=C3)=O)=CC=C2O1 |
| 分子式 | C25H28O6 |
| 分子量 | 424.49 |
| 溶解度 | DMSO: 250 mg/mL (588.94 mM) |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Dihydromunduletone (DHM) is a rotenoid derivative and a selective, potent adhesion G protein-coupled receptor (aGPCR) (GPR56 and GPR114/ADGRG5) antagonist with an IC 50 of 20.9 μM for GPR56, but not inhibit GPR110 or class A GPCRs[1]. [1]. Hannah M. Stoveken, et al. Dihydromunduletone Is a Small-Molecule Selective Adhesion G Protein-Coupled Receptor Antagonist. Mol Pharmacol. 2016 Sep; 90(3): 214-224. |
