Cimlanod (BMS-986231) 是一种治疗心力衰竭的第二代硝基 (HNO) 供体。Cimlanod (BMS-986231) 在血液中性 pH 环境下通过 pH 依赖性化学分解传递 HNO。Cimlanod (BMS-986231) 具有正性促力作用和正性肌力以及血管舒张作用。
| Cas No. | 1620330-72-4 |
| 别名 | BMS-986231; CXL-1427 |
| Canonical SMILES | O=S(C1=CC=C(O1)C)(NO)=O |
| 分子式 | C5H7NO4S |
| 分子量 | 177.18 |
| 溶解度 | DMSO: 125 mg/mL (705.50 mM) |
| 储存条件 | 4°C, protect from light, stored under nitrogen |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Cimlanod (BMS-986231) is a second-generation Nitroxyl (HNO) donor for heart failure. Cimlanod (BMS-986231) delivers HNO via pH-dependent chemical breakdown when exposed to the neutral pH environment of the bloodstream. Cimlanod (BMS-986231) possesses positive lusitropic and inotropic as well as vasodilatory effects[1][2]. [1]. Cowart D, et al. A Phase 1 Randomized Study of Single Intravenous Infusions of the Novel Nitroxyl Donor BMS-986231 in Healthy Volunteers. J Clin Pharmacol. 2019 May;59(5):717-730.
[2]. Felker GM, et al. Rationale and design for the development of a novel nitroxyl donor in patients with acute heart failure. Eur J Heart Fail. 2019 Aug;21(8):1022-1031. |
