BOS-172722 是一种单极纺锤体 1 (MPS1) 检查点抑制剂，对MPS1 (1 mM ATP) 和P-MPS1 的IC50值分别为 11 nM 和 63 nM。它可研究多种乳腺癌。
产品描述
BOS-172722 is an inhibitor of monopolar spindle 1 (MPS1) checkpoint(IC50 of 2 nM).
体外活性
BOS-172722 is an inhibitor of monopolar spindle 1 (MPS1) checkpoint with an IC50 of 2 nM and it also has potential for the treatment of various forms of breast cancer[1].
Cas No.
1578245-44-9
分子式
C24H30N8O
分子量
446.55
储存和溶解度
1M HCl:65 mg/mL (145.56 mM),ultrasonic and adjust pH to 2 with HCl
DMSO:5 mg/mL (11.20 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
