LIT-001 是非肽类催产素受体激动剂，EC50为55 nM，Ki为226 nM。它可改善孤独症小鼠模型的社交互动。
产品描述
LIT-001 improves social interaction in a mouse model of autism.It is the first nonpeptide oxytocin receptor agonist with EC50 of 55 nM and Ki of 226 nM.
体外活性
In the in vitro signal transduction experiment, LITL-001 is an unbiased OT-R agonist, acting on the two main signal transduction pathways of this receptor, with slight antagonistic effect on V1a and agonist effect on V1b receptor, only observed at high concentration.
体内活性
LIT-001 (10-20 mg/kg; i.p.) alleviates core symptoms in the context of autism spectrum disorders (ASD )[1].
Cas No.
2245072-21-1
分子式
C30H34F3N7O4S
分子量
645.7
储存和溶解度
DMSO:247 mg/mL (382.53mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
