2,4-Imidazolidinedione, 1-(3,5-dimethyl-4-(2-((4-oxo-2-(4-(trifluoromethoxy)phenyl)-1,3,8-triazaspiro(4.5)dec-1-en-8-yl)sulfonyl)ethyl)phenyl)-5,5-dimethyl-
PCO371 是口服具有活性的甲状旁腺激素受体 1 的完全抑制剂，对 PTHR2 无作用。
产品描述
PCO371 is an orally active full agonist of parathyroid hormone receptor 1. It has no effect on PTH type 2 receptor.
体外活性
In COS-7 cells expressing hPTHR1, PCO371 causes cAMP production (EC50: 2.4?μM). 2.5 μM in COS-7 cells transfected with hPTHR1-delNT, and also enhances the phospholipase C activity (EC50, 17?μM)[1].
Cas No.
1613373-33-3
分子式
C29H32F3N5O6S
分子量
635.65
别名
2,4-Imidazolidinedione, 1-(3,5-dimethyl-4-(2-((4-oxo-2-(4-(trifluoromethoxy)phenyl)-1,3,8-triazaspiro(4.5)dec-1-en-8-yl)sulfonyl)ethyl)phenyl)-5,5-dimethyl-
储存和溶解度
DMSO:120 mg/mL (188.78 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
