AP C5 选择性抑制鸟苷 3',5'-环单磷酸 (cGMP) 依赖性蛋白激酶 II (cGKII)，pIC50 为 7.2，可用于腹泻病的研究。
| Cas No. | 2234272-10-5 |
| Canonical SMILES | C#CCNC1=NC(C2=CC=C(N3C=CN=C3)C=C2)=CC=N1 |
| 分子式 | C16H13N5 |
| 分子量 | 275.31 |
| 溶解度 | Soluble in DMSO |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Potent and selective protein kinase G type II (PKG2) inhibitor (pIC50 = 7.2). Displays >20-fold selectivity for PKG2 over PKG1 and PKA (pIC50 values are 4.6 and 4.8 for PKG1 and PKA, respectively). Blocks 8-pCPT-cGMP-dependent VASP phosphorylation in intestinal organoids. Also attenuates toxin-stimulated anion secretory responses in mouse intestinal tissue. Bijvelds et al (2018) Selective inhibition of intestinal guanosine 3',5'-cyclic monophosphate signaling by small-molecule protein kinase inhibitors. J.Biol.Chem. 293 8173 PMID:29653944 |
