KCC 07 是一种有效的、选择性的和脑渗透性 MBD2（甲基-CpG 结合域蛋白 2）抑制剂。 KCC 07 阻止 MBD2 与甲基化 DNA 结合并激活脑特异性血管生成抑制剂 1 (BAI1)，诱导抗增殖 BAI1/p53/p21 信号传导。抗癌活性。
| Cas No. | 315702-75-1 |
| Canonical SMILES | OC1=CC=CC(NC2=NC(C3=CC=CC=N3)=CS2)=C1 |
| 分子式 | C14H11N3OS |
| 分子量 | 269.32 |
| 溶解度 | Soluble in DMSO |
| 储存条件 | 4°C, protect from light |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | MBD2 (Methyl-CpG-binding domain protein 2) inhibitor. Prevents binding of MBD2 to methylated DNA and activates brain specific angiogenesis inhibitor 1 (BAI1)/p53 signaling. Inhibits medulloblastoma (MB) cell growth in vitro and reduces tumor size in mice bearing MB xenografts. Brain penetrant. Zhu et al (2018) BAI1 suppresses medulloblastoma formation by protecting p53 from Mdm2-mediated degradation. Cancer Cell 33 1004 PMID:29894688 |
