Hepln-13 是具有口服活性的Hepsin抑制剂(IC50:0.33 μM)。它可用于研究转移性前列腺癌。
产品描述
Hepln-13 is a hepsin inhibitor that acts by hindering prostate cancer bone metastasis.
体外活性
Hepln-13 (10 μM; 2 hours; 293 cells) inhibits cleavage[1].
体内活性
HepIn-13 displays dose-dependent inhibition of Hepsin overexpression-relevant prostate cancer phenotypes in LPB-Tag/PB-Hepsin mice and blocks prostate cancer metastasis in this animal model.
Cas No.
64369-13-7
分子式
C17H13BrN2
分子量
325.2
别名
Hepln 13;Hepln13
储存和溶解度
DMSO:60 mg/mL (184.50 mM,Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
