MMV390048 是一种抗疟药，是一种新型化学疟原虫 PI4K 抑制剂。它与疟原虫 PI4K 的 ATP 结合位点结合，不与除人类 PIP4K2C 外的其他恶性疟原虫和人类激酶结合。

MMV390048 is an antimalarial agent and is a representative of a new chemical class of Plasmodium PI4K inhibitor (Kdapp=0.3 μM). MMV390048 binds to the ATP binding site of Plasmodium PI4K and does not bind to other P. falciparum and human kinases apart from human PIP4K2C, thus alleviating potential kinase-mediated safety concerns.

MMV390048 against the intraerythrocytic life cycle stages of P. falciparum displayed a steep inhibition curve (IC50: IC90 values of 28 and 40 nM, respectively).

1314883-11-8

C18H14F3N3O2S

393.38

DMSO:90 mg/mL (228.79 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years