| CAS NO: | 68076-36-8 |
| Cas No. | 68076-36-8 |
| 别名 | N-叔丁氧羰基-1,4-丁二胺 |
| Canonical SMILES | NCCCCNC(OC(C)(C)C)=O |
| 分子式 | C9H20N2O2 |
| 分子量 | 188.27 |
| 溶解度 | Water: 100 mg/mL (531.15 mM); DMSO: 100 mg/mL (531.15 mM) |
| 储存条件 | 4°C, protect from light, stored under nitrogen |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | NH2-C4-NH-Boc (compound 15) is a PROTAC linker, which refers to the Alkyl/ether composition. NH2-C4-NH-Boc can be used in the synthesis of a series of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. [1]. Jiang F, et al.Discovery of novel small molecule induced selective degradation of the bromodomain and extra-terminal (BET) bromodomain protein BRD4 and BRD2 with cellular potencies.Bioorg Med Chem. 2020 Jan 1;28(1):115181. |
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