D3-βArr 是一种促甲状腺激素受体正变构调节剂，通过直接激活促甲状腺激素受体启动 β-Arr 1 的易位，EC50为 11.6 μM。它还可增强促甲状腺激素介导的体外成骨细胞分化。
产品描述
D3-βArr is a positive allosteric modulator for thyrotropin receptor (TSHR), which initiates translocation of β-Arr 1 (EC50: 11.6 μM) by direct TSHR activation.
体外活性
D3-βArr stimulated β-Arr 1 translocation with an efficacy threefold greater than TSH. The EC50 for β-Arr 1 translocation by D3-βArr was 11.6 μM. D3-βArr (10 μM) increased the efficacy of TSH in the translocation of β-Arr 1 at a maximum of 5.1-fold over TSH alone.
Cas No.
662164-09-2
分子式
C20H23N5
分子量
333.439
别名
NCGC00379308
储存和溶解度
DMSO:100 mg/mL (299.91 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
