AZ3451 是蛋白酶激活受体 2 的变构拮抗剂，IC50值为 23 nM。
产品描述
AZ3451 is an allosteric antagonist of protease-activated receptor-2 (PAR2, IC50: 23 nM).
体外活性
AZ3451 is selective for PAR2 over PAR4 and PAR1 (IC50s =<2.5, 380, and >50,000 nM, respectively, in a β-arrestin-2 recruitment assay). AZ3541 completely inhibits SLIGRL-induced phosphorylation of ERK in 1321N1 astrocytoma cells when used at a concentration of 10 μM.
Cas No.
2100284-59-9
分子式
C30H27BrN4O3
分子量
571.46
储存和溶解度
DMSO:80 mg/mL (140 mM)
H2O:Insoluble
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
