Radioprotectin-1 是特异性的 LPA2 激动剂，对小鼠 LPA2 GPCR 的 EC50 为 25 nM，具有辐射保护和辐射缓解作用。
产品描述
Radioprotectin-1 is a selective agonist of LPA2 with EC50 of 25 nM for murine LPA2 GPCR and exerts radioprotective and radiomitigative action.
体外活性
In MEF and IEC-6 cells expressing LPA2, Radioprotectin-1 (0, 0.1, 0.3, 1.0, and 3 μM) effectively reduces apoptosis induced by gamma-irradiation and the radiomimetic chemotherapeutic Adriamycin[1].
体内活性
In C57BL/6 female mice, Radioprotectin-1 (0.1 and 0.3 mg/kg; s.c.) decreases the mortality in models of the hematopoietic and gastrointestinal acute radiation syndrome[1].
Cas No.
1622006-09-0
分子式
C23H19ClN2O6S
分子量
486.93
储存和溶解度
DMSO:100 mg/mL (205.4 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
