ONO-7300243 是溶血磷脂酸受体 1 (LPA1)拮抗剂，IC50为 0.16 μM。
产品描述
ONO-7300243 is an antagonist of lysophosphatidic acid receptor 1 (LPA1; IC50 : 0.16 μM).
体内活性
The oral administration of ONO-7300243 (17a) to determine its effect on rat IUP. Compound 17a inhibited the LPA-induced IUP increase in a dose-dependent manner (ID50 = 11.6 mg/kg p.o.) up to 1 h after dosing. Significant effects were observed at 10 and 30 mg/kg (p< 0.05 vs vehicle). ONO-7300243 (17a) (30 mg/kg, p.o.) led to a significant decrease in the IUP in conscious rats without LPA stimulation compared with the vehicle without affecting the mean blood pressure (MBP)[1].
Cas No.
638132-34-0
分子式
C28H31NO5
分子量
461.558
储存和溶解度
DMSO:100 mg/mL (216.66 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
