[Pyr1]-Apelin-13 是一种高效的、内源性 apelin 受体选择性激动剂。

[Pyr1]-Apelin-13 is a potent and selective endogenous Apelin receptor (APJ) agonist.

[Pyr1]-apelin-13 encapsulation in lipoPEG particles (lipoPEG-PA13) results in sustained and extended drug release both in vitro and in vivo[1].

[Pyr1]-apelin-13 nanocarriers in a mouse model of pressure-overload induced heart failure demonstrate a sustainable long-term effect of [Pyr1]-apelin-13 in preventing cardiac dysfunction[1]. [Pyr1] apelin-13 (1, 5 μg) improves locomotor activity and reduces pain symptoms, cavity size and caspase-3 levels in rats. [Pyr1] apelin-13 (1, 5 μg) significantly increases thermal paw withdrawal latency. [Pyr1] apelin-13 in 5 μg dose also produces significant attenuation in paw withdrawal threshold than SCI animals from the second week post SCI[2].

217082-60-5

C69H108N22O16S

1533.82

[pGlu1]-Apelin-13;人牛吡啶APELIN-13

H2O:50 mg/mL (32.60 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years