Virodhamine是一种内源性大麻素，是CB1受体的拮抗剂和CB2受体的激动剂。Virodhamine可用于阿尔茨海默病等神经系统疾病的研究。
产品描述
Virodhamine, an endocannabinoid, is an antagonist of CB1 receptor and an agonist of CB2 receptor. Virodhamine can be used for the research of neurological disorders such as Alzheimer's diseases.
体外活性
virodhamine (50nM, 72h) treatment augmented features associated with megakaryocytic development: cells increased adherence and membrane expansion. virodhamine (10, 20, 40 μM, 72h) treatment increases the expression of CD61[1].
体内活性
Virodhamine (1, 5, 10 mg/kg; i.p. once) repairs the nicotine (0.8 mg/kg) and immobilization stress induced anxiety in Male ICR mice[2].
Cas No.
287937-12-6
分子式
C22H37NO2
分子量
347.53
别名
O-arachidonoyl ethanolamine
储存和溶解度
DMSO:90mg/mL (259mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
