BAY 41-2272 是一种直接且不依赖一氧化氮的可溶性鸟苷酸环化酶刺激剂。
产品描述
BAY 41-2272 is a direct and NO-independent soluble guanylate cyclase (sGC) stimulator.
体外活性
In vitro, BAY 41-2272 results in concentration dependent relaxation of human and rabbit cavernosum with EC50 of 489.1 nM and 406.3 nM, respectively. [3]
体内活性
In female spontaneously hypertensive rats, BAY 41-2272 (10 mg/kg, p.o.) shows antiplatelet effect, strongly decreases blood pressure and increases survival. [2] In C. albicans-infected mice, BAY 41-2272 (10 mg/kg, i.p.) markedly increases macrophage-dependent cell influx to the peritoneum in addition to macrophage functions, and reduces the death rate. [4] In db/db-/- type II diabetic and obese mice, BAY 41-2272 improves impaired corpus cavernosum (CC) relaxation. [5]
Cas No.
256376-24-6
分子式
C20H17FN6
分子量
360.396
储存和溶解度
DMSO:36 mg/mL (100 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
