Ataciguat 是一种不依赖一氧化氮的可溶性鸟苷酸环化酶 (sGC) 激活剂，具有血管舒张作用。它能够激活 sGC 的铁血红素铁氧化还原形式，刺激 cGMP 的产生。
产品描述
Ataciguat (HMR-1766) is a potent and specific soluble guanylate cyclase (sGC) activator.
体外活性
Ataciguat induces the relaxation in aortic rings or coronary rings. In the presence of nitric oxide synthase (NOS) inhibitor, the endothelium effect was abolished to DETA-NO or ataciguat, in both vessels. Ataciguat was able to induce NO production in HUVECs cells. In the presence of NOS inhibitor, the NO production induced by ataciguat was abolished[1].
Cas No.
254877-67-3
分子式
C21H19Cl2N3O6S3
分子量
576.48
别名
HMR-1766
储存和溶解度
DMSO:95mg/mL (164.79 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
