RO5028442 是一种高效且有选择性的脑-渗透加压素 1a (V1a) 受体拮抗剂，对人类 (hV1a) 和小鼠 (mV1a) 受体的 Ki 值分别为 1 和 39 nM，可用于研究自闭症的试验。
产品描述
RO5028442 has been used in trials studying Autistic Disorder.
体外活性
RO5028442 (compound 8) has excellent binding in and functional affinity for hV1a, moderate mouse affinity, and excellent selectivity versus human V2 (hV2) and human oxytocin (hOT) receptors. RO5028442 shows high solubility. RO5028442 is found to be highly selective against a panel of 89 targets. Finally, RO5028442 is identified as a suitable compound for clinical studies[1].
Cas No.
920022-47-5
分子式
C25H28ClN3O2
分子量
437.97
别名
RO 5028442
储存和溶解度
DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
