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VH032-PEG3-acetylene
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
VH032-PEG3-acetylene图片
CAS NO:2098799-80-3

VH032-PEG3-acetylene 是一种合成的 E3 连接酶配体-linker 偶联物,包含基于 VH032 的 VHL 配体和 1 个 linker。
Cas No.2098799-80-3
Canonical SMILESO=C(NCC1=CC=C(C2=C(C)N=CS2)C=C1)[C@H]3N(C([C@H](C(C)(C)C)NC(COCCOCCOCC#C)=O)=O)C[C@H](O)C3
分子式C31H42N4O7S
分子量614.75
溶解度DMSO: 50 mg/mL (81.33 mM)
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

VH032-PEG3-acetylene is a synthesized E3 ligase ligand-linker conjugate that incorporates the VH032 based VHL ligand and a linker used in PROTAC technology[1].

[1]. Wurz RP, et al. A "Click Chemistry Platform" for the Rapid Synthesis of Bispecific Molecules for Inducing Protein Degradation. J Med Chem. 2018 Jan 25;61(2):453-461.

 
 
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