Iberdomide 是一种口服有效的 cereblon E3 连接酶调节剂，对 cereblon 结合亲和力的IC50约为150 nM。它是沙利度胺的衍生物，具有抗肿瘤和免疫刺激活性。
产品描述
Iberdomide is a modulator of cereblon( IC50 value of 60 nM in a competitive TR-FRET assay).
体外活性
Iberdomide has a greater potency for degrading the CRL4 complex substrates Ikaros and Aiolos (EC50s = 1 and 0.5 nM) but has no degradative activity for GSPT1 or CK1α[1].
Cas No.
1323403-33-3
分子式
C25H27N3O5
分子量
449.507
别名
CC-220
储存和溶解度
DMSO:30 mg/mL (66.74 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
