MT-802 是一种基于Cereblon配体的、BTK的降解剂，其 DC50=1 nM。它具有研究 C481S突变型慢性淋巴细胞白血病的潜力。
产品描述
MT-802 is an effective BTK degrader based on PROTAC technology (DC50: 1 nM). MT-802 has the potential to treat C481S mutant chronic lymphocytic leukemia (CLL).
体外活性
MT-802 degrades BTK (DC50: 9.1 nM). The maximal degradation was observed by 250 nM.
Cas No.
2231744-29-7
分子式
C41H41N9O8
分子量
787.82
储存和溶解度
DMSO:100 mg/mL (126.93 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
