Pregnenolone Carbonitrile 是一种啮齿动物-PXR 的激活剂，可诱导 CYP3A 的表达。

Pregnenolone Carbonitrile is an activator of rodent-PXR and induces the expression of CYP3A.

Pregnenolone Carbonitrile is hepatoprotective by increasing resistance to subsequent stressful insults[4].

In WT mice, Pregnenolone Carbonitrile (40 mg/kg/day; i.p.) induces the expression of CYP3A11 and CYP2B10 at the mRNA, protein, and enzymatic levels[2]. In adult female Sprague-Dawley rats, Pregnenolone Carbonitrile (100 mg/kg; i.p.) induces the expression of CYP3A mRNA[3]. In male Sprague-Dawley rats, Pregnenolone Carbonitrile (35 mg/kg; gavage) increase in Pgp expression[4].

1434-54-4

C22H31NO2

341.49

5-Pregnen-3β-ol-20-one-16α-carbonitrile;Pregnenolone 16α-carbonitrile

DMSO:30 mg/mL (87.85 mM),ultrasonic and warming and heat to 60°C
Powder: -20°C for 3 years
In solvent: -80°C for 2 years