Pagoclone 是一种 GABA 受体激动剂，可用于治疗口吃、恐慌症和广泛性焦虑的相关研究。 Pagoclone 是含 α1、α2 和 α5 的 GABAA 受体的部分激动剂和含有 α3 亚基的受体的完全激动剂。

Pagoclone is a GABA receptor agonist and can be used for studies on the treatment of stuttering, panic disorder, and generalized anxiety. Pagoclone is a partial agonist at α1-, α2- and α5-containing GABAA receptors and a full agonist at receptors containi

Pagoclone (3 mg/kg, p.o.) produces a dose-dependent increase in time spent on the open arms. Pagoclone (1, 3 or 10 mg/kg) lowers the cumulative chain-pulling response in the response sensitivity test. Plasma pagoclone concentrations are dose-dependent but not linear, with plasma concentrations of pagoclone being 0.4±0.1, 1.1±0.2 and 2.2±0.2 ng/mL, respectively. Pagoclone (3 mg/kg, p.o.) has significant anxiolytic-like activity, but Pagoclone(0.3, 1, 3 mg/kg p.o.) produces a significant reduction in the total distance travelled[1].

133737-32-3

C23H22ClN3O2

407.89

CI1043;IP456;帕戈隆;RP-59037;CI-1043;RP-62955;IP-456

DMSO:Soluble
Powder: -20°C for 3 years
In solvent: -80°C for 2 years