GSK8612 是一种具有高度选择性的TBK1强效抑制剂，其 pIC50=6.8。
产品描述
GSK8612 is a highly selective and potent inhibitor of Tank-binding Kinase-1 (TBK1, pIC50: 6.8) .
体外活性
In cellular assays, GSK8612 inhibited toll-like receptor (TLR)3-induced interferon regulatory factor (IRF)3 phosphorylation in Ramos cells and type I interferon (IFN) secretion in primary human mononuclear cells. In THP1 cells, GSK8612 was able to inhibit secretion of interferon-beta (IFNβ) in response to dsDNA and cGAMP, the natural ligand for STING.
Cas No.
2361659-62-1
分子式
C17H17BrF3N7O2S
分子量
520.33
储存和溶解度
DMSO:100 mg/mL (192.19 mM)
H2O:Insoluble
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
