SR11237 是一种泛视黄醇 X 受体 (RXR) 激动剂。 SR11237 导致 RXR/RXR 同源二聚体形成并反式激活包含 RXR 反应元件的报告基因。
产品描述
SR11237 is a Pan retinoid X receptor (RXR) agonist. SR11237 causes RXR/RXR homodimers to form and transactivate a reporter gene containing a RXR-response element.
体外活性
SR11237 is effective at transactivating a chloramphenicol acetyltransferase reporter gene through RXRs but not retinoic acid receptors in COS-1 cells[2].
体内活性
In Sprague-Dawley rats, SR11237 (BMS-649) (25 mg/kg; i.p.) Caused disturbed ossification and bone morphology in rats, including premature growth plate closure and infiltration of ossified tissue through the central epiphysis[3].
Cas No.
146670-40-8
分子式
C24H28O4
分子量
380.48
别名
SR 11237
储存和溶解度
DMSO:4 mg/mL (10.51 mM),ultrasonic and warming and heat to 60°C
Ethanol:<1 mgml
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
