VU 0240551 是神经元 K-Cl 协同转运蛋白 KCC2 抑制剂的特异性拮抗剂，IC50 为 560 nM。 VU 0240551 抑制 L 型钙通道和 HERG。
产品描述
VU 0240551 is a selective antagonist of neuronal K-Cl cotransporter KCC2 inhibitor with an IC50 of 560 nM. VU 0240551 inhibits L-type calcium channels and hERG.
体外活性
VU 0240551 (0-100 μM) reduces the P cell response to GABA in a concentration-dependent manner and significantly reduces GABA-elicited hyperpolarization at doses of 75 and 100 μM[3].
体内活性
VU 0240551 (10 μM) significantly blocks the chloride influx in cells from euhydrated rats. VU 0240551 doesn't affect cells from Salt-loading rats[4].
Cas No.
893990-34-6
分子式
C16H14N4OS2
分子量
342.44
储存和溶解度
H2O:Insoluble
DMSO:45 mg/mL (131.4 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
