(R)-FT671 是 FT671 的 R 型异构体。 FT671是有效、非共价的、选择性的 USP7 抑制剂,IC50 值为 52 nM,与USP7催化域结合的 Kd 值为 65 nM。
Cas No. | 1959551-27-9 |
Canonical SMILES | O=C1C2=C(N(C3=CC=C(F)C=C3)N=C2)N=CN1CC4(O)CCN(C(C[C@@H](N5N=C(F)C=C5)C(F)F)=O)CC4 |
分子式 | C24H23F4N7O3 |
分子量 | 533.48 |
溶解度 | DMSO: 150 mg/mL (281.17 mM) |
储存条件 | Store at -20°C |
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
产品描述 | (R)-FT671 is the R-isomer of FT671. FT671 is a potent, non-covalent and selective USP7 inhibitor with an IC50 of 52 nM and binds to the USP7 catalytic domain with a Kd of 65 nM[1]. [1]. Turnbull AP, et al. Molecular basis of USP7 inhibition by selective small-molecule inhibitors. Nature. 2017 Oct 26;550(7677):481-486. |