Withaferin A 是从南非醉茄中分离到的一种甾体内酯，是内皮蛋白 C 受体脱落抑制剂，可以抑制NF-kB的活性，具有抗炎，抗肿瘤等作用。它是一种新型 NFkappaB 抑制剂，有望成为治疗各种炎症性疾病和癌症的新型抗炎药。

WITHAFERIN A is a novel class of NFkappaB inhibitors, which hold promise as novel anti-inflammatory agents for treatment of various inflammatory disorders and/or cancer.

WITHAFERIN A,potently inhibits NFkappaB activation by preventing the tumor necrosis factor-induced activation of IkappaB kinase beta via a thioalkylation-sensitive redox mechanism.

WITHAFERIN A Displays Anti-inflammatory Properties in Vivo—Because NFκB is a critical player in the inflammatory signaling pathway and because WITHAFERIN A inhibits NFκB activation.

L929sA cells were co-treated with WITHAFERIN A and DTT for 1 h, and then TNF-induced NFκB activation was examined.

Mice are injected subcutaneously with zymosan in the footpad, and swelling is determined at several time points after the injection. Pretreatment with WITHAFERIN A(intraperitoneal) was performed to evaluate anti-inflammatory effects, whereas DEX (intraperitoneal) was chosen as a positive control. the mean of the differences between the zymosan-treated and untreated footpad for all the three groups. Both DEX.

5119-48-2

C28H38O6

470.606

醉茄素A;醉茄素 A

DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years