Vinorelbine Tartrate 是一种抗有丝分裂剂，能够抑制 Hela 细胞的增殖，IC50值为 1.25 nM。
产品描述
Vinorelbine Tartrate, a semi-synthetic vinca alkaloid, interacts with tubulin resulting in mitosis inhibition.
体外活性
Vinorelbine inhibits microtubule assembly by inducing tubulin aggregation into spirals and paracrystals. [1] Vinorelbine shows potent antiproliferative activity against a series of tumor cells, including human melanoma, non-small-cell lung cancer, breast cancer, etc. [2][3][4]
体内活性
In vivo, Vinorelbine also shows antitumour activity against a series of subcutaneously-implanted human tumour xenografts. [5]
Cas No.
125317-39-7
分子式
C53H66N4O20
分子量
1079.119
别名
Vinorelbine Tartrate;KW-2307;酒石酸长春瑞滨;长春瑞滨酒石酸盐;Navelbine tartrate;Nor-5'-anhydrovinblastine ditartrate
储存和溶解度
H2O:107.9 mg/mL (100 mM)
DMSO:107.9 mg/mL (100 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
