Pratensein 是黄酮类化合物,能够减少氧化损伤和恢复突触和 BDNF 水平,改善 β-淀粉样蛋白诱导的大鼠认知障碍。
产品描述
Pratensein as a novel transcriptional up-regulator of scavenger receptor class B type I in HepG2 cells.
体外活性
Protective effect of five isoflavones (formononetin, daidzein, Pratensein, calycosin and irilone) from Trifolium pratense on lipopolysaccharide-induced dopaminergic neurodegeneration was studied for the first time. The results showed that all five isoflavones attenuated LPS-induced decrease in dopamine uptake and the number of dopaminergic neurons in a dose-dependent manner in rat mesencephalic neuron-glia cultures. Moreover, they also significantly inhibited LPS-induced activation of microglia and production of tumor necrosis factor-alpha, nitric oxide and superoxide in mesencephalic neuron-glia cultures and microglia-enriched cultures. In addition, the rank order of protective potency of five isoflavones was: Pratensein>daidzein>calycosin>formononetin>irilone.
Cas No.
2284-31-3
分子式
C16H12O6
分子量
300.26
别名
红车轴草素;三叶草
储存和溶解度
(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years