Protosappanin B 是从苏木中提取的一种多酚类天然产物，具有抗肿瘤作用。它通过激活 Mdm2 依赖性泛素化过程诱导 p53 蛋白降解。它显著提高细胞活力，抑制细胞凋亡并上调生长相关蛋白 43 的表达。

1. Protosappanin B significantly increases cell viability, inhibits cell apoptosis and up-regulates the expression of growth-associated protein 43. 2. Protosappanin B induces the degradation of p53 protein, via activation of a MDM2-dependent ubiquitination process.

102036-29-3

C16H16O6

304.298

原苏木素B;FT-0689654;Q-100961

DMSO:55 mg/mL(180.7 mM)
Chloroform, Dichloromethane, Ethyl Acetate, Acetone, etc.:Soluble
Powder: -20°C for 3 years
In solvent: -80°C for 2 years