Dehydrocorydaline是一种生物碱。它调节Bax，BCL-2蛋白表达，激活Caspase-7，Caspase-8，并使PARP失活。它能增强p38 MAPK活化，具有抗炎、抗癌等功效。它具有强大的抗疟疾作用，并具低细胞毒性。

1. Dehydrocorydaline exerts anti-metastatic potential via suppression of MMPs and Bcl-2 signaling in NSCLC cells. 2. Dehydrocorydaline stimulates p38 MAPK activation, which can enhance heterodimerization of MyoD and E proteins, thus resulting in MyoD activation and myoblast differentiation. 3. Dehydrocorydaline shows antiplatelet effects, it inhibits thrombin-induced platelet aggregation in a low dose ( IC50= 34.914 ug/mL). 4. Dehydrocorydaline has anti-inflammatory and antinociceptive effects. 5. Dehydrocorydaline inhibits MCF-7 cell proliferation by inducing apoptosis mediated by regulating Bax/Bcl-2, activating caspases as well as cleaving PARP.

30045-16-0

C22H24NO4

366.436

Dehydrocorydalin;13-Methylpalmatine;脱氢紫堇碱

DMSO:66 mg/mL(180.1 mM)
Chloroform, Dichloromethane, Ethyl Acetate, Acetone, etc.:Soluble
Powder: -20°C for 3 years
In solvent: -80°C for 2 years