Koumine 是一种从钩吻中得到的生物碱，具有高效抗肿瘤活性，在肿瘤细胞中能够提高 Bax/BCL-2 的蛋白比例和 Caspase-3 的表达。在类风湿性关节炎动物模型中，它能够预防关节炎的发展。它具有抗焦虑、抗应激、抗银屑病作用，也可用于缓解疼痛的研究。

1. Koumine can treat the diabetic neuropathy. 2. Koumine has antineoplastic effect, may be a future breast cancer chemotherapeutic agent. 3. Koumine has a significant analgesic effect in rodent behavioral models of inflammatory and neuropathic pain, the mechanism may be associated with the upregulation of allopregnanolone in the spinal cord.

1358-76-5

C20H22N2O

306.409

Chloroform, Dichloromethane, Ethyl Acetate, Acetone, etc.:Soluble
DMSO:14 mg/mL(45.7 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years