Nitidine chloride 是从Zanthoxylum nitidum (Roxb) DC 中分离得到的，具有抗疟疾活性。它通过多个靶点通路，起抗癌作用，抑制STAT3、DNA拓扑异构酶1和2A、ERK和c-Src/FAK相关信号通路。它通过MAPK和NF-kB途径抑制Lps诱导的炎性细胞因子的产生。

1. Nitidine chloride has inhibitory effects on various tumors, such as renal cancer , breast cancer. 2. Nitidine chloride inhibits the proliferation of SMMC-7721 cells in vitro in a time- and dose-dependent manner and identifies efficacy in vivo in a mouse model of HCC.

13063-04-2

C21H18ClNO4

383.83

Chloroform, Dichloromethane, Ethyl Acetate, Acetone, etc.:Soluble
DMSO:10 mg/mL(26.1 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years