Beclomethasone dipropionate(Beclomethasone)

Molecular Weight (MW)	521.04
Formula	C28H37ClO7
CAS No.	5534-09-8
Storage	-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)	DMSO: 104 mg/mL (199.6 mM)
Water: <1 mg/mL
Ethanol: 18 mg/mL (34.5 mM)
Other info	Chemical Name: (8S,9R,10S,11S,13S,14S,16S,17R)-9-chloro-11-hydroxy-10,13,16-trimethyl-3-oxo-17-[2-(propionyloxy)acetyl]-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl propionate InChi Key: KUVIULQEHSCUHY-XYWKZLDCSA-N InChi Code: InChI=1S/C28H37ClO7/c1-6-23(33)35-15-22(32)28(36-24(34)7-2)16(3)12-20-19-9-8-17-13-18(30)10-11-25(17,4)27(19,29)21(31)14-26(20,28)5/h10-11,13,16,19-21,31H,6-9,12,14-15H2,1-5H3/t16-,19-,20-,21-,25-,26-,27-,28-/m0/s1 SMILES Code: CCC(O[C@]1(C(COC(CC)=O)=O)[C@@H](C)C[C@@]2([H])[C@]3([H])CCC4=CC(C=C[C@]4(C)[C@@]3(Cl)[C@@H](O)C[C@]12C)=O)=O
Synonyms	Beclomethasone dipropionate; Clenil; Qvar; Beconase; alanase; Vancenase; Beclometasone dipropionate

Molecular Weight (MW)

521.04

Formula

C28H37ClO7

CAS No.

5534-09-8

Storage

-20℃ for 3 years in powder form

-80℃ for 2 years in solvent

Solubility (In vitro)

DMSO: 104 mg/mL (199.6 mM)

Water: <1 mg/mL

Ethanol: 18 mg/mL (34.5 mM)

Other info

Chemical Name: (8S,9R,10S,11S,13S,14S,16S,17R)-9-chloro-11-hydroxy-10,13,16-trimethyl-3-oxo-17-[2-(propionyloxy)acetyl]-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl propionate

InChi Key: KUVIULQEHSCUHY-XYWKZLDCSA-N

InChi Code: InChI=1S/C28H37ClO7/c1-6-23(33)35-15-22(32)28(36-24(34)7-2)16(3)12-20-19-9-8-17-13-18(30)10-11-25(17,4)27(19,29)21(31)14-26(20,28)5/h10-11,13,16,19-21,31H,6-9,12,14-15H2,1-5H3/t16-,19-,20-,21-,25-,26-,27-,28-/m0/s1

SMILES Code: CCC(O[C@]1(C(COC(CC)=O)=O)[C@@H](C)C[C@@]2([H])[C@]3([H])CCC4=CC(C=C[C@]4(C)[C@@]3(Cl)[C@@H](O)C[C@]12C)=O)=O

Synonyms

Beclomethasone dipropionate; Clenil; Qvar; Beconase; alanase; Vancenase; Beclometasone dipropionate

In Vitro	In vitro activity: Beclomethasone dipropionate (BDP) is an anti-inflammatory corticosteroid available for the treatment of asthma and allergic rhinitis (AR). BDP is previously developed as aqueous nasal formulations for the treatment of AR. BDP is also available in dry nasal aerosol formulations as chlorofluoro carbon (CFC) metered-dose inhaler nasal sprays, but CFC-containing formulations have been withdrawn from the market and currently are not available.BDP hydrofluoroalkane (HFA) inhalation aerosol currently is available for patient use and indicated for the maintenance treatment of asthma as prophylactic therapy in patients 5 years of age and older.BDP HFA nasal aerosol, an intranasal aerosol formulation, has been developed recently for the treatment of AR.
In Vivo
Animal model
Formulation & Dosage
References	Clin Ther. 2012 Jun;34(6):1422-31; J Allergy Clin Immunol. 1999 Dec;104(6):1215-22.

In Vitro

In vitro activity: Beclomethasone dipropionate (BDP) is an anti-inflammatory corticosteroid available for the treatment of asthma and allergic rhinitis (AR). BDP is previously developed as aqueous nasal formulations for the treatment of AR. BDP is also available in dry nasal aerosol formulations as chlorofluoro carbon (CFC) metered-dose inhaler nasal sprays, but CFC-containing formulations have been withdrawn from the market and currently are not available.BDP hydrofluoroalkane (HFA) inhalation aerosol currently is available for patient use and indicated for the maintenance treatment of asthma as prophylactic therapy in patients 5 years of age and older.BDP HFA nasal aerosol, an intranasal aerosol formulation, has been developed recently for the treatment of AR.

In Vivo

Animal model

Formulation & Dosage

References

Clin Ther. 2012 Jun;34(6):1422-31; J Allergy Clin Immunol. 1999 Dec;104(6):1215-22.

CAS NO:	5534-09-8
规格:	≥98%

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