Zandelisib 是PI3K抑制剂，对p110δ选择性抑制，IC50为 3.5 nM，详细信息请参考专利文献 WO2019183226 A1 中的化合物 1。它显示出抗肿瘤作用。
产品描述
Zandelisib is an inhibitor of phosphatidylinositol 3-kinase (PI3K)(p110δ, IC50 of 3.5 nM), and with antineoplastic activity.
体外活性
Zandelisib inhibits PI3Ks(p110α, p110β, p110γ and p110δ with IC50s of 4, 976 nM, 605 nM, 817 nM and 3.5 nM, respectivey)[1].
Cas No.
1401436-95-0
分子式
C31H38F2N8O
分子量
576.68
储存和溶解度
DMSO:33.33 mg/mL (57.80 mM),Need ultrasonic and warming and adjust pH to 3 with HCl and heat to 60°C
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
