MMAF-OMe是一种抗微管蛋白剂，能够抑制 MDAMB435/5T4，MDAMB361DYT2，MDAMB468 和 Raji (5T4-) 这四种肿瘤细胞，IC50值分别为 0.056 nM，0.166 nM，0.183 nM 和 0.449 nM。它也是ADC细胞毒素。
产品描述
MMAF-OMe is an antitubulin agent which inhibits several tumor cell lines with IC50s of 0.056 nM, 0.166 nM, 0.183 nM, and 0.449 nM for MDAMB435/5T4, MDAMB361DYT2, MDAMB468, and Raji (5T4-) cell lines, respectively. MMAF-Ome is also an ADC cytotoxin.
体外活性
2.5F-Fc and 2.5F-Fc-MMAF have similar IC50?values (6.9±1.1 vs. 8.3±1.3 nM, respectively)[1]. MMAF conjugation has negligible impact on integrin-binding affinity[1].
Cas No.
863971-12-4
分子式
C40H67N5O8
分子量
745.99
别名
Monomethyl auristatin F methyl ester
储存和溶解度
DMSO:99 mg/mL (132.70 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
