Pixantrone dimaleate 是一种拓扑异构酶 II 的抑制剂和 DNA 嵌入剂，是一种实验性抗肿瘤药物。

Pixantrone dimaleate (BBR 2778 dimaleate) is an experimental antineoplastic drug.

Recombinant RT enzymes are expressed, purified, and assessed for inhibition by Efavirenz (L-743726). Ki and Kii values are determined for each enzyme tested. The wild-type RT exhibited exclusively noncompetitive inhibition kinetics (data not shown), and, therefore, the Ki and Kii values are identical. Pure noncompetitive inhibition is not assumed for the mutant enzymes, and, hence, the values of both Ki and Kii are obtained from the linear mixed-type inhibition equation. The two- to threefold differences between the Ki and Kii values probably reflect a small contribution of competitive inhibition with the mutant RTs[1].

144675-97-8

C25H27N5O10

557.516

BBR 2778 dimaleate;BBR-2778;匹克生琼来酸盐;马来酸匹衫琼;Pixantrone Maleate

DMSO:91 mg/mL(163.3 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years