PTACH 是一种有效的HDAC抑制剂，对HDAC1，HDAC4和HDAC6的IC50分别为 48 nM，32 nM 和 41 nM。PTACH 对多种癌细胞具有强大的生长抑制作用 (EC50为 1.1-9.1 μM)。
产品描述
PTACH (NCH-51) is a SAHA-based inhibitor of human HDAC. It can potently inhibit the growth of various human Y cells (EC50: 1 to 10 μM).
激酶实验
mTOR and PI3K Cellular Assays: Cellular IC50 values for mTOR are determined using p53?/? MEFs. Cells are treated with vehicle or increasing concentrations of Torin 2 for 1 h and then lyse. Phosphorylation of S6K1 Thr-389 is monitored by immunoblotting using a phospho-specific antibody. Meanwhile, cellular IC50 values for PI3Ka are determined based on phosphorylation of Akt Thr-308 in p53?/?/mLST8?/? MEFs or human PC3 cells expressing the S473D mutant of Akt1.
Cas No.
848354-66-5
分子式
C20H26N2O2S2
分子量
390.56
别名
Cpd 51;NCH-51
储存和溶解度
DMSO:26 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
