Niraparib R-enantiomer 是一种PARP1抑制剂，IC50为 2.4 nM。
产品描述
Niraparib R-enantiomer is an inhibitor of PARP1(IC50 of 2.4 nM).
体外活性
Niraparib R-enantiomer has somewhat lower in vitro metabolic clearance than the Niraparib S-enantiomer in rat liver microsomes, but Niraparib S-enantiomer is more potent in cell based assays (PARylation EC50, Niraparib R-enantiomer=30 nM, Niraparib S-enantiomer=4.0 nM; BRCA1-HeLa CC50, Niraparib R-enantiomer=470, Niraparib S-enantiomer=34 nM). [1].
Cas No.
1038915-58-0
分子式
C19H20N4O
分子量
320.39
别名
Niraparib R-enantiomer;MK 4827 (R-enantiomer)
储存和溶解度
DMSO:30 mg/mL (93.63 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
