FTBMT 是一种选择性的GPR52激动剂(EC50:75 nM)，具有抗精神病和促进认知的作用。
产品描述
FTBMT is a selective GPR52 agonist (EC50: 75 nM) and it also has antipsychotic and procognitive properties.
体外活性
In CHO cells expressing human, mouse, or rat GPR52, FTBMT (0.1-10 μM) improves intracellular cAMP levels (pEC50s of 7.03, 6.85, and 6.87, respectively)[2].
体内活性
In rats, FTBMT (3 or 10 mg/kg, 48 hours) improves recognition and spatial working memory. FTBMT (30 mg/kg, 90 minutes) shows antipsychotic-like activity without causing catalepsy in mice[2]
Cas No.
1358575-02-6
分子式
C19H16F4N4O
分子量
392.35
储存和溶解度
H2O:< 0.1 mg/mL (insoluble)
DMSO:45 mg/mL (114.69 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
