Oleoylethanolamide 是一种PPAR-α 的高亲和力内源性激动剂，可用于肥胖和动脉硬化的相关研究。
产品描述
Oleoylethanolamide is a high affinity endogenous agonist of PPAR-α.
体外活性
In vitro studies showed that OEA inhibited transforming growth factor β1-stimulated HSCs activation through suppressing Smad2/3 phosphorylation, α-SMA expression and myofibroblast transformation.
体内活性
Treatment with OEA (5 mg/kg/day, intraperitoneal injection, i.p.) significantly attenuated the progress of liver fibrosis in both two experimental animal models by blocking the activation of hepatic stellate cells (HSCs).?Gene expression analysis of hepatic tissues indicated that OEA inhibited the expression of α-smooth muscle action (α-SMA) and collagen matrix, fibrosis markers, and genes involved in inflammation and extracellular matrix remodeling.
Cas No.
111-58-0
分子式
C20H39NO2
分子量
325.53
别名
Oleamide MEA;Oleic acid monoethanolamide;油酰单乙醇胺;N-Oleoylethanolamide
储存和溶解度
DMSO:19.83 mg/mL (60.92 mM),Need ultrasonic
H2O:< 0.1 mg/mL (insoluble)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
