AGK2 是一种选择性SIRT2抑制剂，其IC50值为 3.5 μM。它抑制 SIRT1 和 SIRT3，IC50值分别为 30 和 91 μM。
产品描述
AGK2（IC50=3.5 μM） is an effective, and specific SIRT2 inhibitor.
体外活性
In SIRT2-myc-expressing HeLa cells, AGK2 effectively inhibits the activity of SIRT2, and increases acetylated tubulin. AGK2 protects dopaminergic neurons from α-Syn–induced toxicity in primary midbrain cultures. [1] AGK2 induces both necrosis and caspase-3-dependent apoptosis in C6 glioma cells. [2] SIRT2 also decreases merlin-mutant viability of mouse schwann cells (MSCs) without substantially reducing wild-type MSC viability. [3]
体内活性
In drosophila model of parkinson's disease, AGK2 rescues α-Syn–mediated toxicity and modify aggregation. [1]
Cas No.
304896-28-4
分子式
C23H13Cl2N3O2
分子量
434.28
别名
2-氰基-3-[5-(2,5-二氯苯基)-2-呋喃基]-N-5-喹啉基-2-丙烯酰胺
储存和溶解度
DMSO:4.3 mg/mL (10 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
