YK-3-237 是 SIRT1 激活剂，靶向突变体 p53。它抑制三阴性乳腺癌细胞的增殖。
产品描述
YK-3-237 reduces acetylation of mtp53 and exhibits anti-proliferative effects toward triple-negative breast cancer (TNBC) cells carrying mtp53.
体外活性
YK-3-237 activates SIRT1 enzyme activities in vitro and deacetylation of both mtp53 in a SIRT1-dependent manner.
Cas No.
1215281-19-8
分子式
C19H21BO7
分子量
372.18
别名
B-[2-Methoxy-5-[(1E)-3-oxo-3-(3,4,5-trimethoxyphenyl)-1-propen-1-yl]phenyl]boronic acid
储存和溶解度
DMF:30 mg/ml(80.60 mM)
Ethanol:10 mg/ml(26.86 mM)
DMSO:30 mg/ml(80.60 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
