N-CaffeoyLTRyptophan 是一种潜在的 Sirt 抑制剂，使用咖啡提取物进行筛选。 N-CaffeoyLTRyptophan 抑制 Sirt2 (IC50; 8.7 μM) 优于 Sirt1 (IC50; 34μM)。

N-Caffeoyltryptophan, a potential Sirt inhibitor, is screened using coffee extract. N-Caffeoyltryptophan inhibited Sirt2 (IC50; 8.7 μM) better than Sirt1(IC50; 34μM).

In cellular levels,N-Caffeoyltryptophan was able to increase the acetylation of total lysine, cortactin and histone H3 in neuronal NG108-15 cells. In the same cells, the amide also increased the acetylation of lysine (K382) in p53, but not (K305)[1].

109163-69-1

C20H18N2O5

366.373

trans-Caffeoyl-L-tryptophan;反式咖啡酰-L-色氨酸

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years