DUB-IN-2 是一种有效的去泛素酶抑制剂，能够抑制 USP8 的活性，IC50值为 0.28 μM。

Dub-in-2, with an IC50 value of 0.28 for USP8, is an effective deubiquitinase inhibitor.

DUBs-IN-2 inhibits the viability of HCT116 colon cell line and PC-3 prostate cancer cell line with IC50 values of 0.5-1.5?μM.DUBs-IN-2 is a potent USP8 inhibitor with an IC50 of 0.28 μM, and has no effect on USP7, with an IC50 of >100 μM.

924296-19-5

C15H9N5O

275.26

DMSO:9.06 mg/mL (32.91 mM),Need ultrasonic and warming
Powder: -20°C for 3 years
In solvent: -80°C for 2 years