DUB-IN-1 是一种泛素特异性蛋白酶 (USP) 的活性抑制剂，对 USP8 的IC50值为 0.24 μM。

DUB-IN-1, with an IC50 value of 0.24 for USP8, is an active inhibitor of ubiquitin-specific protease (USPs).

DUBs-IN-1 is inactive toward USP7 (IC50, >100 μM). DUBs-IN-1 and its analogs reduce the viability of HCT116 colon and PC-3 prostate cancer cell lines with IC50s ranging from 0.5 μM to 1.5?μM.DUBs-IN-1 (22 f) is an active inhibitor of ubiquitin-specific proteases, with an IC50 of 0.24 μM for USP8.

924296-18-4

C20H11N5O

337.33

DMSO:99 mg/mL (293.48 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years