SM-276001 是可口服的干扰素诱导剂，是选择性TLR7激动剂，可以诱导抗肿瘤免疫反应。
产品描述
SM-276001 is a potent selective agonist of TLR7,and is an orally active interferon (IFN) inducer.
体外活性
SM-276001 (1 nM-10 μM) dose-dependently activates NF-κB through human TLR7 [2].
体内活性
Oral administration of 0.1 mg/kg SM-276001 in mice shows potent IFN-inducing activity [1]. Twice weekly oral administration of SM-276001 at a dose of 3 mg/kg significantly reduced disease burden in mice bearing either Renca or CT26 tumors.[2].
Cas No.
473930-22-2
分子式
C16H21N7O
分子量
327.38
储存和溶解度
DMSO:100 mg/mL (305.46 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
