CU-CPT17e 是多Toll样受体激动剂，可激活TLR3、TLR8和TLR9。

CU-CPT17e is a potent agonist of TLR(TLR3, TLR8, and TLR9).

The first small molecule 17e (CU-CPT17e) capable of simultaneously activating TLRs 3, 8, and 9.?Biochemical studies demonstrated that 17e could induce a strong immune response via the production of various cytokines in human monocytic THP-1 cells.?Furthermore, 17e inhibited the proliferation of HeLa cancer cells by triggering apoptosis and arresting the cell cycle at the S phase.?These results showcase potential therapeutic applications of 17e in both vaccine adjuvants and anticancer therapies based on multi-TLR activation.

2109805-75-4

C27H24N2O8

504.49

DMSO:10 mM,Need ultrasonic and warming
Powder: -20°C for 3 years
In solvent: -80°C for 2 years